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Volume 5
Main Index

Issue 1


Potential Anticancer Agents.1 LXII. The Relationship of Chemical Structure to Antileukem'c Activity with Analogs of 1-Methyl-3-nitro-1-nitrosoguanidine (NSC-9369). II
Karen A. Hyde, Edward Acton, W. A. Skinner, Leon Goodman, Joseph Greenberg, and B. R. Baker
pp 1 - 14; DOI:
10.1021/jm01236a001
PDF
Synthesis of Potential Anticancer Agents. XXX. (1-Aziridinyl)purines
J. A. Montgomery, K. Hewson, and C. Temple
pp 15 - 24; DOI:
10.1021/jm01236a002
PDF
Complex Esters of Thioinosinic-(5′) Acid
H. Jeanette Thomas and John A. Montgomery
pp 24 - 32; DOI:
10.1021/jm01236a003
PDF
para-[N-Bis-(2-chloroethyl)]-aminobenzoylglutamic Acid
S.-C. J. Fu
pp 33 - 41; DOI:
10.1021/jm01236a004
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Synthesis of Peptides of 1-Aminocyclopentanecarboxylic Acid
S. Shankman, S. Higa, F. Lew, and M. E. Roberts
pp 42 - 49; DOI:
10.1021/jm01236a005
PDF
Pyridoxal Hydrazine Derivatives for Cancer Chemotherapy
Richard H. Wiley and Gether Irick
pp 49 - 53; DOI:
10.1021/jm01236a006
PDF
2-tert-Butyl-10-(3-dimethylaminopropyl)-phenothiazine and Related Compounds
Francis Sowinski and Harry L. Yale
pp 54 - 63; DOI:
10.1021/jm01236a007
PDF
Some Analogs of Chlordiazepoxide
S. C. Bell, C. Gochman, and S. J. Childress
pp 63 - 69; DOI:
10.1021/jm01236a008
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Indanols. IV.1 Indanoxypropanolamines
Seymour L. Shapiro, Vincent A. Parrino, Elaine S. Isaacs, and Louis Freedman
pp 69 - 76; DOI:
10.1021/jm01236a009
PDF
α-Benzyltetrahydrofurfurylamines--a New Series of Psychomotor Stimulants. I
Robert L. Clarke and Louis S. Harris
pp 77 - 95; DOI:
10.1021/jm01236a010
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Hypotensive Agents. 2-(2-Aminoethyl)-piperidine Derivatives
William F. Minor, Justin B. Hoekstra, Dorothea Fisher, and Joseph Sam
pp 96 - 107; DOI:
10.1021/jm01236a011
PDF
16-Substituted Steroids. XVIII.1 6,16-Difunctional 3,5-Cyclo-5α-androstanes
James R. Rhone, Max N. Huffman, and Allan J. Stanley
pp 107 - 111; DOI:
10.1021/jm01236a012
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The Solvolysis of 21-Hydrocortisone Esters and Hemiesters
Edward R. Garrett
pp 112 - 133; DOI:
10.1021/jm01236a013
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Certain Steroid Ketals and Their Biological Activity
William S. Allen, Henry M. Kissman, Sidney Mauer, Ira Ringler, and Martin J. Weiss
pp 133 - 155; DOI:
10.1021/jm01236a014
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Mercury Derivatives of Allylhydantoins
Franklyn W. Gubitz and William B. McKeon
pp 168 - 175; DOI:
10.1021/jm01236a015
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Potential Uricosuric Agents Derived from 1,3-Diphenylbarbituric Acid
Homer C. Scarborough and Gordon R. McKinney
pp 175 - 183; DOI:
10.1021/jm01236a016
PDF
Large Scale Preparation and Purification of the Vasopressor Polypeptide, Substance A
C. G. Huggins and E. J. Walaszek
pp 183 - 190; DOI:
10.1021/jm01236a017
PDF
Penetration of Brain and Brain Tumor by Aromatic Compounds as a Function of Molecular Substituents. III
A. H. Soloway, B. Whitman, and J. R. Messer
pp 191 - 196; DOI:
10.1021/jm01236a018
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Aspects of the Metabolism of Isoniazid and Acetylisoniazid in the Human and the Dog
Allen S. Yard and Herbert McKennis
pp 196 - 203; DOI:
10.1021/jm01236a019
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A Metabolic Study of α-Methyl-β-(3,4-dihydroxyphenyl)-DL-alanine in Man
Theodore L. Sourkes, Gerard F. Murphy, and Beatriz Chavez-Lara
pp 204 - 210; DOI:
10.1021/jm01236a020
PDF
Comparison between the Rate Constants for Acetylation of Sulfonamides in Vivo and O/W Partition Coefficient
Eino Nelson
pp 211 - 214; DOI:
10.1021/jm01236a021
PDF
The Mechanism of Action of the 2-Phenylcyclopropylamine Type of Monoamine Oxidase Inhibitors
B. Belleau and J. Moran
pp 215 - 219; DOI:
10.1021/jm01236a022
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Book Review

pp 220 - 220; DOI:
10.1021/jm01236a023
PDF
Synthesis of Sulfonylhydrazine Derivatives with Monoamine Oxidase Inhibitory Activity
C. S. Rooney, Edward J. Cragoe, Jr, Curt C. Porter, and James M. Sprague
pp 155 - 167; DOI:
10.1021/jm01236a600
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Issue 2


Chemistry and Pharmacology of Monoamine Oxidase Inhibitors: Hydrazine Derivatives
Floyd E. Anderson, Daniel Kaminsky, Bernard Dubnick, Sylvester R. Klutchko, Wiaczeslaw A. Cetenko, Jonas Gylys, and John A. Hart
pp 221 - 230; DOI:
10.1021/jm01237a001
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Hypoglycemic Activity in Relation to Chemical Structure of Potential Oral Antidiabetic Substances. I. 1-Sulfonyl-3-alkylureas
Bernt Hökfelt and Åke Jönsson
pp 231 - 239; DOI:
10.1021/jm01237a002
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Hypoglycemic Activity in Relation to Chemical Structure of Potential Oral Antidiabetic Substances. II. Analogs of 1-Sulfonyl-3-alkylureas
Bernt Hökfelt and Åke Jönsson
pp 240 - 246; DOI:
10.1021/jm01237a003
PDF
Hypoglycemic Activity in Relation to Chemical Structure of Potential Oral Antidiabetic Substances. III. 2-Benzenesulfonamido-5-alkyl-1,3,4-thiadiazoles and -oxadiazoles
Bernt Hökfelt and Åke Jönsson
pp 247 - 257; DOI:
10.1021/jm01237a004
PDF
Dihydro-1,3-oxazines as Antitumor Agents
M. E. Kuehne and E. A. Konopka
pp 257 - 280; DOI:
10.1021/jm01237a005
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Steroidal Dihydro-1,3-oxazines as Antitumor Agents
M. E. Kuehne, E. A. Konopka, and B. F. Lambert
pp 281 - 296; DOI:
10.1021/jm01237a006
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Antineoplastic Agents. IV. Mannich Base Nitrogen Mustards (Part A)1,2,3
George R. Pettit and Joseph A. Settepani
pp 296 - 302; DOI:
10.1021/jm01237a007
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6-Acylamido- and 6-Acylamido-9(or 7)-acylpurines
Arnold H. Schein
pp 302 - 311; DOI:
10.1021/jm01237a008
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Structure-Activity Relationships of 3-Substituted Dihydrobenzothiadiazine Diuretics
Richard M. Taylor and John G. Topliss
pp 312 - 320; DOI:
10.1021/jm01237a009
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Coumestrol, Plant Phenolics, and Synthetic Estrogens: a Correlation of Structure and Activity
Robert A. Micheli, A. N. Booth, A. L. Livingston, and E. M. Bickoff
pp 321 - 335; DOI:
10.1021/jm01237a010
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Oxazolocoumarins
Robert Bruce Moffett
pp 335 - 340; DOI:
10.1021/jm01237a011
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3-Substituted Tropane Derivatives. III. 3-Substituted Tropane Carbinols, Alkenes, and Alkanes
Charles L. Zirkle, Elvin L. Anderson, Paul N. Craig, Fred R. Gerns, Zena K. Indik, and Alex M. Pavloff
pp 341 - 356; DOI:
10.1021/jm01237a012
PDF
Structures Related to Morphine. XXII.1 A Benzomorphan Congener of Meperidine
Hiroshi Kugita, Seiichi Saito, and Everette L. May
pp 357 - 361; DOI:
10.1021/jm01237a013
PDF
α-Benzyltetrahydrofurfurylamines--A New Series of Psychomotor Stimulants. II.1 Resolution of Isomers
Robert L. Clarke, B. F. Tullar, and Louis S. Harris
pp 362 - 372; DOI:
10.1021/jm01237a014
PDF
Dialkylaminoalkyl Derivatives of 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene and Related Compounds
Frank J. Villani, Claire A. Ellis, Carol Teichman, and Catherine Bigos
pp 373 - 383; DOI:
10.1021/jm01237a015
PDF
The Anticonvulsant Activity of 1,2,4-Triazoles
C. Ainsworth, Nelson R. Easton, M. Livezey, D. E. Morrison, and W. R. Gibson
pp 383 - 389; DOI:
10.1021/jm01237a016
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Derivatives of 8-Hydroxy-2-quinolineacrylic Acid. II
Madhukar G. Vaidya and Joseph G. Cannon
pp 389 - 397; DOI:
10.1021/jm01237a017
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Synthesis of Potential Anticancer Agents. VII. Some 3-Chloropropionyl Amides1-3
Frank D. Popp, Ernest Cullen, Robert B. Davis, and Warren Kirsch
pp 398 - 403; DOI:
10.1021/jm01237a018
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An Improved Procedure for Preparing 1-Methylpyridinium-2-aldoxime Chloride
Robert I. Ellin, David Easterday, and Albert A. Kondritzer
pp 404 - 405; DOI:
10.1021/jm01237a019
PDF
Steroids. CLXXX.1 2-Methyl-Δ2-androstenes and 2-Methylene-androstanes. A New Class of Potent Anabolic Agents
A. D. Cross, J. A. Edwards, and A. Bowers
pp 406 - 408; DOI:
10.1021/jm01237a020
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Steroids. CLXXXIV.1 2-Formyl-Δ2-androstenes and Related Compounds. A New Class of Potent Anabolic Agents
J. C. Orr, O. Halpern, and A. Bowers
pp 409 - 411; DOI:
10.1021/jm01237a021
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Book Review

pp 412 - 412; DOI:
10.1021/jm01237a022
PDF

Issue 3


Synthesis and Biological Properties of 9-Sarcosine Oxytocin
William D. Cash, Logan McCulloch Mahaffey, Alfred S. Buck, Donald E. Nettleton, Christos Romas, and Vincent du Vigneaud
pp 413 - 423; DOI:
10.1021/jm01238a001
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Isomeric 2-Acetoxytropine Methiodides
S. Archer, A. M. Lands, and T. R. Lewis
pp 423 - 430; DOI:
10.1021/jm01238a002
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Synthesis and Analgesic Activity of a New Bridged Heterocyclic System
H. E. Zaugg, R. W. DeNet, and E. T. Kimura
pp 430 - 440; DOI:
10.1021/jm01238a003
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Analgetics Based on the Pyrrolidine Ring. II.
J. F. Cavalla, R. A. Selway, J. Wax, L. Scotti, and C. V. Winder
pp 441 - 451; DOI:
10.1021/jm01238a004
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Structure-Activity Relationships in a Series of Anticonvulsant and Hypnotic Bicyclic Carboxamides
Werner R. Boehme, Estelle A. Siegmund, William G. Scharpf, and Edgar Schipper
pp 451 - 464; DOI:
10.1021/jm01238a005
PDF
The Synthesis and γ-Aminobutyric Acid Transaminase Inhibition of Aminoöxy Acids and Related Compounds
E. L. Schumann, L. A. Paquette, R. V. Heinzelman, D. P. Wallach, J. P. DaVanzo, and M. E. Greig
pp 464 - 477; DOI:
10.1021/jm01238a006
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Anabolic Agents: Derivatives of 2-Halo-5α-androst-1-ene
R. E. Counsell and P. D. Klimstra
pp 477 - 483; DOI:
10.1021/jm01238a007
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The Metabolites of Ergometrine and Lysergic Acid Diethylamide in Rat Bile
M. B. Slaytor and S. E. Wright
pp 483 - 491; DOI:
10.1021/jm01238a008
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The Fate and Excretion of Polythiazide1 in the Dog
Rex Pinson, Eric C. Schreiber, Edward H. Wiseman, Josephine Chiaini, and Doris Baumgartner
pp 491 - 503; DOI:
10.1021/jm01238a009
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Monoamine Oxidase Inhibitors. III. Structural Variations in 1-Alkyl and 1-Aralkyl-1(or 2)-acylhydrazines
Thomas S. Gardner, Edward Wenis, and John Lee
pp 503 - 513; DOI:
10.1021/jm01238a010
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Reduction of Nitrofurans. I. Aminofurans
Frank F. Ebetino, James J. Carroll, and Gabriel Gever
pp 513 - 524; DOI:
10.1021/jm01238a011
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The Metabolism of 5-Nitro-2-furaldehyde Acetylhydrazone
Joanne Olivard, Salvatore Valenti, and James A. Buzard
pp 524 - 531; DOI:
10.1021/jm01238a012
PDF
Synthesis and Biological Activity of Pyridoxine Analogs
Shreekrishna M. Gadekar, Jean L. Frederick, and Edward C. DeRenzo
pp 531 - 538; DOI:
10.1021/jm01238a013
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6-Deoxytetracyclines. II. Nitrations and Subsequent Reactions
J. Petisi, J. L. Spencer, J. J. Hlavka, and J. H. Boothe
pp 538 - 546; DOI:
10.1021/jm01238a014
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Synthetic Amebicides. VI. Benzo[b][1,8]phenanthrolines, Benzo[b][1,10]phenanthrolines, Dibenzo[b,h][1,6]naphthyridines, and Benzo[h]quino[4,3-b]quinolines
Edward F. Elslager and Frank H. Tendick
pp 546 - 558; DOI:
10.1021/jm01238a015
PDF
Potential Purine Antagonists. XXXI. The Preparation of Certain 9-Alkyl-2-amino-6-purinethiols and Related Derivatives as Antitumor Agents
C. Wayne Noell and Roland K. Robins
pp 558 - 588; DOI:
10.1021/jm01238a016
PDF
Potential Purine Antagonists. XXXII. The Synthesis and Antitumor Activity of Certain Compounds Related to 4-Aminopyrazolo[3,4-d]pyrimidine
Edward Y. Sutcliffe, K. Y. Zee-Cheng, C. C. Cheng, and Roland K. Robins
pp 588 - 607; DOI:
10.1021/jm01238a017
PDF
The Preparation and Antitumor Activity of Certain Derivatives of 6-Mercaptopurine
Leland R. Lewis, C. Wayne Noell, Alden G. Beaman, and Roland K. Robins
pp 607 - 617; DOI:
10.1021/jm01238a018
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Potential Hypoglycemic Agents: 1,3,4-Oxadiazoles and Related Compounds
J. B. O'Neal, H. Rosen, P. B. Russell, A. C. Adams, and A. Blumenthal
pp 617 - 626; DOI:
10.1021/jm01238a019
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Synthesis of Potential Anticancer Agents. VIII. Benzaldehyde Mustard Derivatives and Related Compounds
Frank D. Popp
pp 627 - 629; DOI:
10.1021/jm01238a020
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Microbiological Transformation of Strophanthidin
Charles J. Sih, S. Morris Kupchan, O. El Tayeb, and Adriano Afonso
pp 629 - 633; DOI:
10.1021/jm01238a021
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New Benzomorphan Analgetics
Maxwell Gordon, John J. Lafferty, David H. Tedeschi, Blaine M. Sutton, Nathan B. Eddy, and Everett L. May
pp 633 - 635; DOI:
10.1021/jm01238a022
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Blockade of Adrenergic α-Receptors by a Carbonium Ion
B. Belleau and D. J. Triggle
pp 636 - 639; DOI:
10.1021/jm01238a023
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Pyrimidines. VIII. Pyrimidine Derivatives of Thioguanine
H. C. Koppel, Robert Henre Springer, Roland K. Robins, and C. C. Cheng
pp 639 - 641; DOI:
10.1021/jm01238a024
PDF
Intestinal Anthelmintics. I. The Preparation of Bis(2,4,5-trichlorophenol)-Piperazine Salt (Triclofenol Piperazine) and Other Phenol-Piperazine Salts
Franklin W. Short and Edward F. Elslager
pp 642 - 646; DOI:
10.1021/jm01238a025
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Synthetic Amebicides. VII. 6,6′-Diallyl-α,α′-bis(dialkylaminoalkylamino)-4,4′-bi-o -cresols
Edward F. Elslager and Frank H. Tendick
pp 646 - 651; DOI:
10.1021/jm01238a026
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Preparation of Amidines by Catalytic Reduction of Amidoximes
Robert P. Mull, Renat H. Mizzoni, Mary R. Dapero, and Mary E. Egbert
pp 651 - 654; DOI:
10.1021/jm01238a027
PDF
Non-classical Antimetabolites. VII.1,2 The Bridge Principle of Specificity with Exo-alkylating Irreversible Inhibitors
B. R. Baker
pp 654 - 656; DOI:
10.1021/jm01238a028
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Tumor Inhibitors. I. Aristolochic Acid, the Active Principle of Aristolochia indica
S. Morris Kupchan and Raymond W. Doskotch
pp 657 - 659; DOI:
10.1021/jm01238a029
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α,β-Unsaturated Ketone Derivatives of Aryloxyacetic Acids, a New Class of Diuretics
Everett M. Schultz, Edward J. Cragoe, John B. Bicking, William A. Bolhofer, and James M. Sprague
pp 660 - 662; DOI:
10.1021/jm01238a030
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Book Reviews

pp 663 - 664; DOI:
10.1021/jm01238a031
PDF

Issue 4


Chemistry and Structure-Activity Relationships of Mecamylamine and Derivatives
Clement A. Stone, Mary L. Torchiana, Katherine L. Meckelnberg, John Stavorski, Meyer Sletzinger, Gustav A. Stein, William V. Ruyle, Donald F. Reinhold, Walter A. Gaines, Heinz Arnold, and Karl Pfister
pp 665 - 690; DOI:
10.1021/jm01239a001
PDF
Veratrum Alkaloids. XLIX.1 The Structures and Configurations of Sabine and Sabadine2,3
S. Morris Kupchan, Norbert Gruenfeld, and N. Katsui
pp 690 - 714; DOI:
10.1021/jm01239a002
PDF
Degradation of Corticosteroids. VII. The Synthesis of 7-Membered Ring-A Enol-Lactones
E. Caspi, Y. W. Chang, and R. I. Dorfman
pp 714 - 719; DOI:
10.1021/jm01239a003
PDF
Hypocholesterolemic Agents. I. 20α-(2-Dialkylaminoethyl)aminopregn-5-en-3β-ol Derivatives
R. E. Counsell, P. D. Klimstra, R. E. Ranney, and D. L. Cook
pp 720 - 729; DOI:
10.1021/jm01239a004
PDF
Thyroxine Analogs. VI.1 Synthesis and Antigoitrogenic Activity of 3,5-Diiodo-4-(4′-Aminophenoxy)-L-Phenylalanines, Including the 4′-Amino Analog of 3,5,3′-Triiodo-L-Thyronine
Eugene C. Jorgensen and Peter Slade
pp 729 - 738; DOI:
10.1021/jm01239a005
PDF
Studies on Monoamine Oxidase Inhibitors. I. The Autoxidation of β-Phenylisopropylhydrazine as a Model Reaction for Irreversible Monoamine Oxidase Inhibition
L. E. Eberson and K. Persson
pp 738 - 752; DOI:
10.1021/jm01239a006
PDF
Pyrrolidines. VII. 3-Hydroxy-1-Pyrrolidinecarboxylic Acid Esters
Yao-Hua Wu, William A. Gould, Walter G. Lobeck, Herbert R. Roth, and R. F. Feldkamp
pp 752 - 762; DOI:
10.1021/jm01239a007
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Pyrrolidines. VIII. 3-Acyloxy-3-Aryl-1-Ethyl-and -1-Methylpyrrolidines
Yao-Hua Wu, Walter G. Lobeck, and R. F. Feldkamp
pp 762 - 769; DOI:
10.1021/jm01239a008
PDF
Structure-Activity Relationships in a Series of Anticonvulsant Bicyclic Acylureas
Werner R. Boehme, Estelle A. Siegmund, William G. Scharpf, and Edgar Schipper
pp 769 - 775; DOI:
10.1021/jm01239a009
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Some Aspects of the Chemistry of 5-Ethyl-6-phenyl-meta-thiazane-2,4-dione, an Anesthetic Agent
Robert G. Taborsky and Roland J. Starkey
pp 775 - 780; DOI:
10.1021/jm01239a010
PDF
Acetylenic Amines. III. The Haloethynyl Derivatives
C. W. Ryan, Nelson R. Easton, Robert D. Dillard, and Francis G. Henderson
pp 780 - 784; DOI:
10.1021/jm01239a011
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Synthesis and Hypotensive Activity of Unsymmetrically Substituted Acetylenic Bis-Quaternary Ammonium Compounds and Certain of Their Reduction Products
John L. Neumeyer, Joseph G. Cannon, and Joseph P. Buckley
pp 784 - 792; DOI:
10.1021/jm01239a012
PDF
Apparent Dissociation Constants of Haloaralkylamines
Seymour L. Shapiro, Elaine S. Isaacs, Victor Bandurco, and Louis Freedman
pp 793 - 799; DOI:
10.1021/jm01239a013
PDF
Antineoplastic Agents. V. The Aromatic System of Podophyllotoxin (Part B)1-3
George R. Pettit, Michael F. Baumann, and K. N. Rangammal
pp 800 - 808; DOI:
10.1021/jm01239a014
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The Syntheses and Pharmacological Activities of Amide, Sulfamide, and Urea Derivatives of 4,6-Diaminopyrimidines
John J. Traverso, E. Brown Robbins, and Calvert W. Whitehead
pp 808 - 815; DOI:
10.1021/jm01239a015
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Antidiabetic Agents. N4-Arylsulfonylsemicarbazides
John B. Wright and Robert E. Willette
pp 815 - 822; DOI:
10.1021/jm01239a016
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Antituberculous Agents. II.1 N,N′-Diisopropylethylenediamine and Analogs
R. G. Shepherd and R. G. Wilkinson
pp 823 - 835; DOI:
10.1021/jm01239a017
PDF
Antituberculous Agents. III. (+)-2,2 -(Ethylenediimino)-di-1-butanol1,2 and Some Analogs
R. G. Wilkinson, M. B. Cantrall, and R. G. Shepherd
pp 835 - 845; DOI:
10.1021/jm01239a018
PDF
Antiradiation Compounds. II. Dithiocarbamates
William O. Foye and James Mickles
pp 846 - 852; DOI:
10.1021/jm01239a019
PDF
Synthesis of Chromogenic Substrates for the Assay of Aminopeptidase Activity
Theodore P. Goldstein, Robert E. Plapinger, Marvin M. Nachlas, and Arnold M. Seligman
pp 852 - 857; DOI:
10.1021/jm01239a020
PDF
The Biological Activity of Certain 17α,20; 20,21-Bismethylenedioxy Corticoid Derivatives
Martin J. Weiss, Robert E. Schaub, and Sidney Mauer
pp 858 - 861; DOI:
10.1021/jm01239a021
PDF
Synthesis of Sydnones and Sydnone Imines
Claude V. Greco, Wayne H. Nyberg, and C. C. Cheng
pp 861 - 865; DOI:
10.1021/jm01239a022
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Synthesis of Potential Antineoplastic Agents. XXXI. 9-Alkyl-9H-Purines
Carroll Temple, Conrad L. Kussner, and John A. Montgomery
pp 866 - 870; DOI:
10.1021/jm01239a023
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Synthesis and Biological Activity of Some 4-(Substituted)aminopyrimidines
Hayim Segal, Charles Hedgcoth, and Charles G. Skinner
pp 871 - 876; DOI:
10.1021/jm01239a024
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C(19)-Substituted Steroid Hormone Analogs. I. 17β-Hydroxy-3-oxoandrost-4-ene-19-nitrile
Timothy Jen and Manfred E. Wolff
pp 876 - 878; DOI:
10.1021/jm01239a025
PDF
Book Reviews

pp 879 - 882; DOI:
10.1021/jm01239a026
PDF

Issue 5


Bicyclic Bases. IV.1 Aryl Substituted Bridged Hydroisoindolines
George I. Poos, Margaret M. Lehman, Elizabeth B. Landis, and Janet D. Rosenau
pp 883 - 896; DOI:
10.1021/jm01240a001
PDF
Synthesis and Diuretic Activity of 3,3-Spiro-Substituted Hydrothiazides
Edward J. Cragoe, Otto W. Woltersdorf, John E. Baer, and James M. Sprague
pp 896 - 912; DOI:
10.1021/jm01240a002
PDF
Strong Analgesics. Some 1-Substituted 4-Phenyl-4-Propionoxypiperidines
Philip M. Carabateas and Leonard Grumbach
pp 913 - 919; DOI:
10.1021/jm01240a003
PDF
Dicarbamates and Thiolcarbamates
George deStevens, Marylou Sklar, Halina Lukaszewski, and Lloyd Witkin
pp 919 - 924; DOI:
10.1021/jm01240a004
PDF
Structure-Activity Relationships of Ethylenimines. II. Methyl-Substituted Derivatives of Tetramin
Albert T. Bottini and Vasu Dev
pp 925 - 932; DOI:
10.1021/jm01240a005
PDF
Structure-Activity Relationships of 1-[3-Indolyl)alkyl]-4-arylpiperazines. A New Series of Tranquilizers
David W. Wylie and S. Archer
pp 932 - 943; DOI:
10.1021/jm01240a006
PDF
Guanidines with Antihypertensive Activity. II
Robert P. Mull, Renat H. Mizzoni, Mary R. Dapero, and Mary E. Egbert
pp 944 - 949; DOI:
10.1021/jm01240a007
PDF
Synthesis of Certain C-2 and C-6 Substituted Derivatives of 9α-Fluoro-16α-hydroxyhydrocortisone 16,17-Acetonide
Henry M. Kissman, Arlene Small Hoffman, John F. Poletto, and Martin J. Weiss
pp 950 - 962; DOI:
10.1021/jm01240a008
PDF
Synthesis of Certain 16α-Substituted Derivatives of 9α-Fluoro-11-dehydrocorticosterone, Progesterone and Deoxycorticosterone
Arlene Small Hoffman, Henry M. Kissman, and Martin J. Weiss
pp 962 - 975; DOI:
10.1021/jm01240a009
PDF
16-Alkylated Progesterones
Elliot Shapiro, Theodore Legatt, Lois Weber, Merl Steinberg, A. Watnick, M. Eisler, Marilyn Gilmore Hennessey, C. T. Coniglio, W. Charney, and Eugene P. Oliveto
pp 975 - 988; DOI:
10.1021/jm01240a010
PDF
Cardiac Activity of Newer Digitalis Glycosides and Aglycones
Francis G. Henderson and K. K. Chen
pp 988 - 995; DOI:
10.1021/jm01240a011
PDF
Synthesis and Antitumor Activity of 2-Amino-1-methylpurine-6-thione
C. Wayne Noell, Donald W. Smith, and Ronald K. Robins
pp 996 - 999; DOI:
10.1021/jm01240a012
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Synthesis of Potential “Dual Antagonists.” I. Some Bis(1-aziridinyl)phosphinyl Carbamates1 and Their Structural Analogs
Zinon B. Papanastassiou and Thomas J. Bardos
pp 1000 - 1007; DOI:
10.1021/jm01240a013
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Synthesis of Compounds Related to 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloroethanea
Kwang Yuen Zee-Cheng and C. C. Cheng
pp 1008 - 1015; DOI:
10.1021/jm01240a014
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Derivatives of 6-Aminopenicillanic Acid. III. Reactions with N-Substituted Phthalamic Acids
Y. G. Perron, W. F. Minor, L. B. Crast, A. Gourevitch, J. Lein, and L. C. Cheney
pp 1016 - 1025; DOI:
10.1021/jm01240a015
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N(α-D-Penicilloyl) Amines as Univalent Hapten Inhibitors of Antibody-Dependent Allergic Reactions to Penicillin
Bernard B. Levine
pp 1025 - 1034; DOI:
10.1021/jm01240a016
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In vitro Metabolism of 2-Chloro-10-(3-dimethylaminopropyl)-phenothiazine. III. Isolation and Identification of Metabolites
John J. Ross, Thomas L. Flanagan, and Alfred R. Maass
pp 1035 - 1041; DOI:
10.1021/jm01240a017
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Chemotherapeutic Nitrofurans. VIII.1 The Synthesis of Certain 3,4-Dichloro-5-nitrofurans
Julian G. Michels, Gabriel Gever, and Peter H. L. Wei
pp 1042 - 1048; DOI:
10.1021/jm01240a018
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Disubstituted Progesterones. The 6,16-Chloro and Methyl Series
Richard T. Rapala and Mauriec J. Murray
pp 1049 - 1053; DOI:
10.1021/jm01240a019
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Some New Synthetic Flavonoid Glycosides Related in Structure to Phlorizin
Donald F. Diedrich
pp 1054 - 1062; DOI:
10.1021/jm01240a020
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1,8-Naphthyridine Derivatives. A New Class of Chemotherapeutic Agents
George Y. Lesher, Ernest J. Froelich, Monte D. Gruett, John Hays Bailey, and R. Pauline Brundage
pp 1063 - 1065; DOI:
10.1021/jm01240a021
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Book Reviews

pp 1066 - 1066; DOI:
10.1021/jm01240a022
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Issue 6


The Synthesis of 6-Fluoro-9-methylpurine
Alden G. Beaman and Roland K. Robins
pp 1067 - 1074; DOI:
10.1021/jm01241a001
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The Antitumor Activity of 2-Amino-6-alkylthio-9-(β-D-ribofuranosylpurines and related Derivatives of 2-Amino-6-purinethiol (Thioguanine)
C. Wayne Noell and Roland K. Robins
pp 1074 - 1085; DOI:
10.1021/jm01241a002
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Pyrimidines. IX. 4- and 5-(Substituted-anilino)pyrimidines
Darrell E. O'Brien, Fred Baiocchi, Roland K. Robins, and C. C. Cheng
pp 1085 - 1103; DOI:
10.1021/jm01241a003
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5-Benzyl-2,4-diaminopyrimidines as Antibacterial Agents. I. Synthesis and Antibacterial Activity in vitro
Barbara Roth, Elvira A. Falco, George H. Hitchings, and S. R. M. Bushby
pp 1103 - 1123; DOI:
10.1021/jm01241a004
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Synthesis of Aminosugar Nucleosides
Calvin L. Stevens and K. Nagarajan
pp 1124 - 1148; DOI:
10.1021/jm01241a005
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9-Amino-2,3-dimethoxy-6-nitroacridine 10-Oxides
Edward F. Elslager and Frank H. Tendick
pp 1149 - 1153; DOI:
10.1021/jm01241a006
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4-(3-Chloro-9-acridinylamino)-α-amino-o-cresol 10-Oxides
Edward F. Elslager and Frank H. Tendick
pp 1153 - 1158; DOI:
10.1021/jm01241a007
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3-Chloro-9-(4-diethylamino-1-methylbutylamino)acridine 10-Oxide and other 9-Aminoacridine N-Oxides
Edward F. Elslager, Ralph E. Bowman, Frank H. Tendick, David J. Tivey, and Donald F. Worth
pp 1159 - 1176; DOI:
10.1021/jm01241a008
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Mono- and Difluorination of Steroids at C-16 through Enamine Intermediates
Arthur H. Goldkamp
pp 1176 - 1187; DOI:
10.1021/jm01241a009
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The Synthesis of Some Acidic Amino Acids Possessing Neuropharmacological Activity
J. C. Watkins
pp 1187 - 1199; DOI:
10.1021/jm01241a010
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New Psychotropic Agents.1 II. Derivatives of 5,6-Dihydrodibenz[b,e]azepine (5,6-Dihydromorphanthridine)
Stanley O. Winthrop, M. A. Davis, F. Herr, J. Stewart, and Roger Gaudry
pp 1199 - 1206; DOI:
10.1021/jm01241a011
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New Psychotropic Agents.1 III. Derivatives of 6,11-Dihydrodibenz[b,e]oxepine and 6,11-Dihydrodibenzo[b,e]thiepine
Stanley O. Winthrop, M. A. Davis, F. Herr, J. Stewart, and Roger Gaudry
pp 1207 - 1215; DOI:
10.1021/jm01241a012
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Hypocholesterolemic Agents. II.1 2β-Halo-5α-androstane Derivatives
P. D. Klimstra and R. E. Counsell
pp 1216 - 1224; DOI:
10.1021/jm01241a013
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Hypocholesterolemic Agents. III.1 N-Methyl-N-(dialkylamino)alkyl-17β-aminoandrost-5-en-3β-ol Derivatives
R. E. Counsell, P. D. Klimstra, and R. E. Ranney
pp 1224 - 1233; DOI:
10.1021/jm01241a014
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A Chemical and Pharmacological Study of Some Compounds Derived from 3,4-Xylidine
Dinah M. James and Alun H. Rees
pp 1234 - 1238; DOI:
10.1021/jm01241a015
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5-Isonitrosorhodanines
Frances C. Brown, Constance M. Harris, and Frances Perry
pp 1239 - 1243; DOI:
10.1021/jm01241a016
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2-Substituted Cyclopropylamines. I. Derivatives and Analogs of 2-Phenylcyclopropylamine
Carl Kaiser, Bruce M. Lester, Charles L. Zirkle, Alfred Burger, Charles S. Davis, Thomas J. Delia, and Ludwig Zirngibl
pp 1243 - 1265; DOI:
10.1021/jm01241a017
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2-Substituted Cyclopropylamines. II. Effect of Structure upon Monoamine Oxidase-Inhibitory Activity as Measured in Vivo by Potentiation of Tryptamine Convulsions
Charles L. Zirkle, Carl Kaiser, David H. Tedeschi, Ralph E. Tedeschi, and Alfred Burger
pp 1265 - 1284; DOI:
10.1021/jm01241a018
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Researches in the Series of 1,4-Benzodioxane. XXIV. Synthesis and Pharmacological Properties of Some 2-(1-Aminoethyl)-1,4-benzodioxanes
D. Misiti, F. De Marchi, V. Rosnati, and D. Bovet
pp 1285 - 1293; DOI:
10.1021/jm01241a019
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The Effect of Methoxyphenyl Substitutions on the Strychnine-Like Activity of Aryldiazaadamantanones and Aryldiazaadamantanols
S. Chiavarelli, L. V. Fennoy, G. Settimj, and Leonor De Baran
pp 1293 - 1297; DOI:
10.1021/jm01241a020
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Selective Adrenal Cortical and Gonadal Inhibitors
W. L. Bencze and L. I. Barsky
pp 1298 - 1306; DOI:
10.1021/jm01241a021
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Thyroxine Analogs. VIII.1 3-Methyl- and 3,5-Dimethyl-DL-thyronines and Iodinated Derivatives
Eugene C. Jorgensen and Robert A. Wiley
pp 1307 - 1315; DOI:
10.1021/jm01241a022
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A Study of the Reaction of the Ascorbic-Dehydroascorbic Acid System and Related Model Compounds with Amphetamine
Harold R. Nace and Kenneth F. King
pp 1316 - 1327; DOI:
10.1021/jm01241a023
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Acetylhydrazine as an Intermediate in the Metabolism of Aroylhydrazines
Lennox B. Turnbull, Allan S. Yard, and Herbert McKennis
pp 1327 - 1334; DOI:
10.1021/jm01241a024
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Sulfanilamidopyrimidines. II.1 4-Sulfanilamidopyrimidines and Certain 4,6-Disubstituted Pyrimidines2
W. E. Taft and R. G. Shepherd
pp 1335 - 1341; DOI:
10.1021/jm01241a025
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Toxic Constituents of Rayless Goldenrod
L. H. Zalkow, N. Burke, G. Cabat, and E. A. Grula
pp 1342 - 1351; DOI:
10.1021/jm01241a026
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Steroids. CLXXV. Further Steroidal Anabolic Agents
P. G. Holton and E. Necoechea
pp 1352 - 1357; DOI:
10.1021/jm01241a027
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Spasmolytic 1,2,5-Trisubstituted Pyrroles
N. P. Buu-Hoï, Richard Rips, and Charles Derappe
pp 1357 - 1362; DOI:
10.1021/jm01241a028
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Phenyl-bridged Analogs of Phenylbutazone
Harman S. Lowrie
pp 1362 - 1364; DOI:
10.1021/jm01241a029
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Methanesulfonates of Tertiary and Quaternary Amino Alcohols
Sara Ginsburg
pp 1364 - 1367; DOI:
10.1021/jm01241a030
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Aldehyde Hydrazone Derivatives in Cancer Chemotherapy
Richard H. Wiley and R. L. Clevenger
pp 1367 - 1371; DOI:
10.1021/jm01241a031
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Penetration of Brain and Brain Tumors by Intravascular Injection of Alkylating Agents. IV
Albert H. Soloway, Emery Nyilas, Raymond N. Kjellberg, and Vernon H. Mark
pp 1371 - 1376; DOI:
10.1021/jm01241a032
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Constituents of Cocculus Leaeba DC--Correction for Mistaken Botanical Identity
A. V. Subbaratnam and William B. Cook
pp 1376 - 1378; DOI:
10.1021/jm01241a033
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Some 2-Substituted 2H-1,4-Benzoxazin-3(4H)-ones
Keith W. Wheeler
pp 1378 - 1383; DOI:
10.1021/jm01241a034
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Book Reviews

pp 1384 - 1384; DOI:
10.1021/jm01241a036
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ERRATUM: Chemistry and Structure-Activity Relationships of Mecamylamine and Derivatives
Clement A. Stone, Mary L. Torchiana, Meyer Sletzinger, Gustav A. Stein, William V. Ruyle, Donald F. Reinhold, Walter A. Gaines, Heinz Arnold, and Karl Pfister
pp 1385 - 1385; DOI:
10.1021/jm01241a037
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